Developed by:

The development of CALM was initiated at MSD where it was realized that storage of medication at home did not always occur under the optimal conditions. MSD partnered with AntTail to co-develop CALM which has successfully been implemented in patient programs by various hospitals. In this case MSD acted as the customer who identified a need which enabled AntTail to build their first product and kickstart their business.

What was the cause:

Strict guidelines apply during manufacturing, storage and transport of medication. But once medicines leave the pharmacy, there is no longer control on how they are stored at home.

Some medications must be kept in refrigerated storage at the appropriate temperature. If drugs are stored incorrectly, it may affect the efficacy and safety of the drug. Research shows that not all patients store their medicines correctly at home. The researchers discovered that only one in fourteen patients follow the exact refrigeration guidelines. This means that as much as 93% of temperature-sensitive drugs are not stored correctly at home¹.

What was the purpose:

To maintain the conditions required for temperature-sensitive medications, during transport from pharmacy to home, and for as long as the medication is stored at home. By doing this as optimally as possible, waste is prevented and a contribution to reducing disease activity may be achieved.

Which solution was developed:

Temperature-sensitive information is packaged in a sealed package with an intelligent sensor. This sensor constantly measures the temperature through real-time monitoring. The patient can borrow a CALM cooler to store the drug at the correct temperature (continuously between 2 and 8 degrees Celsius). This active cooling solution replaces the kitchen refrigerator and can even provide cooling for 10 hours when traveling. In addition to the temperature, the sensor also records if and when the packaging is opened. If this is not done at the correct time, the patient will automatically receive an administration reminder via the app.

Physicians and/or pharmacists can access real-time data through an online dashboard, with user approval, to monitor treatment goals. If treatment goals are not achieved, the patient can be contacted to find out why the agreements made regarding the timely and correct use of the medication are not being met. This enables increased compliance and may make the treatment more effective.

1 Vlieland, Nicolas D., et al. “The majority of patients do not store their biologic disease-modifying antirheumatic drugs within the recommended temperature range.” Rheumatology 55.4 (2015): 704-70